Clinical Research Directory

Inclusion Criteria: * Age 18 years or older. * Confirmed or suspected infection as assessed by the treating physician based on symptoms, signs, laboratory findings, imaging findings, microbiological findings, or evidence of an infection source, with systemic antimicrobial therapy initiated or planned. * Does not meet the protocol-defined criteria for sepsis at enrollment. In the setting of confirmed or suspected infection, there must be no acute increase of 2 or more points in the Sequential Organ Failure Assessment 2 score from baseline that is attributable to infection. * Expected by the treating physician to remain in the intensive care unit for more than 48 hours after enrollment. * Written informed consent provided by the participant or the participant's legally authorized representative. Exclusion Criteria: * Sepsis diagnosed at intensive care unit admission or fulfillment of the Sepsis-3 criteria at screening. * Insufficient clinical data to determine the baseline SOFA-2 score according to the prespecified assessment criteria. * Patients with limited nursing care (patients for whom active treatment has been withdrawn) * No blood sample is available on the day of enrollment. * Considered unsuitable for participation by the investigator.