Clinical Research Directory

Inclusion Criteria: * Adults presenting to the Emergency Department with suspected infection * Written informed consent provided prior to enrolment * Evidence of significant physiological disturbance, defined by abnormal vital signs requiring further medical assessment * Symptoms suggestive of a respiratory tract infection (e.g. cough with sputum, worsening cough, or breathing difficulties) * Symptoms suggestive of a urinary tract infection (e.g. pain during urination, frequent urination, or urgency) * Pain, redness, warmth, or discharge at the site of a vascular catheter or intravenous line * Signs of a skin or soft tissue infection, including pain, tenderness, swelling, redness, warmth, or pus formation * Nausea, vomiting, abdominal pain, or jaundice suggestive of a possible abdominal infection * Headache, neck stiffness, or other symptoms suggestive of a central nervous system infection * Abnormal vital signs corresponding to a National Early Warning Score (NEWS) of ≥3 points Exclusion Criteria: * Known pregnancy at the time of study enrolment * Antibiotic treatment that started more than 24 hours before presentation to the Emergency Department * Inability or unwillingness to provide written informed consent for study participation