Clinical Research Directory

Inclusion Criteria: * Male and female participants aged 18 to 70 years. * Fitzpatrick skin phototypes I, II, III, or IV. * Intact skin at the application site. * Willingness to comply with all study procedures and attend scheduled clinic visits for medical assessments, patch applications, and patch readings. * Ability to understand the study requirements, provide written informed consent, and sign the Informed Consent Form (ICF). For the phototest procedure, only participants with Fitzpatrick skin phototypes II and III will be eligible. Exclusion Criteria: * Pregnant or breastfeeding women, or women at risk of becoming pregnant during the study. * Use of anti-inflammatory medications within 30 days prior to screening or immunosuppressive medications within 3 months prior to screening. * Immunosuppression due to medication use or active disease. * Uncontrolled endocrine disorders. * Personal history of atopy. * Intense sun exposure or tanning sessions within 15 days prior to assessment or during the study period. * Planned intense sun exposure or tanning sessions during the study period. * Planned sea bathing, swimming pool use, or sauna sessions during the study period. * Participation in water sports during the study period. * Dermographism. * Use of oral or topical vitamin A acid (retinoids) or related derivatives within 1 week prior to study initiation. * Aesthetic and/or dermatological body treatments within 3 weeks prior to screening. * Scheduled vaccination during the study period or within 3 weeks prior to screening. * History of sensitization, irritation, or photosensitization to topical products. * Active local or generalized skin diseases that may interfere with study assessments. * Skin hyperreactivity. * Initiation of new medications during the study period. * Previous participation in studies involving the same investigational product. * Congenital or acquired immunodeficiency. * Relevant medical history or current evidence of alcohol or substance abuse. * Known or suspected intolerance to any ingredient contained in the investigational or comparator products. * History of poor compliance or unwillingness to comply with the study protocol. * Employees of the study site, sponsor, or their immediate family members directly involved in the study. * Any other condition that, in the investigator's opinion, may interfere with study participation or justify exclusion from the study. Additional Exclusion Criteria for the Phototest: * History of diseases aggravated or triggered by ultraviolet radiation. * Use of photosensitizing medications. * History or current presence of photodermatoses. * Personal or family history of skin cancer. * Presence of precancerous skin lesions, including melanocytic nevi or actinic keratoses, that may interfere with study assessments.