Clinical Research Directory
Browse clinical research sites, groups, and studies.
Comparing Advanced Technologies to Standard Testing for the Diagnosis of Airway Disease in Hospital and Community Settings
Sponsor: University Hospital Southampton NHS Foundation Trust
Summary
Airway disease, such as chronic obstructive pulmonary disease (COPD), is usually diagnosed through breathing tests like spirometry. However, it requires people to blow forcefully into a machine several times which can be uncomfortable and difficult for some patients. This study is looking at whether newer technologies and other breathing tests can help diagnose COPD as accurately as standard testing. We will compare these tests in both hospital and community settings. We are interested in understanding how practical and cost-effective these tests are, including how easy they are to use and how comfortable they are for patients to perform.
Official title: BREATHE: Benchmarking Respiratory Evaluation of Advanced Technologies for Healthcare Excellence
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2026-09
Completion Date
2029-09
Last Updated
2026-09-04
Healthy Volunteers
No
Interventions
Capnography
Capnography used in combination with machine learning-derived algorithms, with or without reversibility testing (if indicated on spirometry)
Oscillometry
Oscillometry (where applicable), with or without reversibility testing (if indicated on spirometry). Measures respiratory impedance during normal tidal breathing.
FENO
Fractional exhaled nitric oxide (if requested). Used to assess airway inflammation.
Gas Transfer
Assesses lung diffusing capacity, performed using full pulmonary function testing equipment
Static Lung Volumes
Body plethysmography (if applicable). Used to assess static lung volumes and, where applicable, specific resistance, performed using full lung function equipment
Spirometry
Spirometry, with or without reversibility testing
Locations (2)
Hampshire Hospitals NHS Foundation Trust
Andover, Hampshire, United Kingdom
University Hospital Southampton NHS Foundation Trust
Southampton, Hampshire, United Kingdom