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COMPLETED
NCT07798804
NA

Frequency- and Intensity-Dependent After-Effects of High-Definition Transcranial Alternating Current Stimulation on Resting-State Electroencephalography

Sponsor: Shanghai Mental Health Center

View on ClinicalTrials.gov

Summary

This study aims to investigate the after-effects of high-definition transcranial alternating current stimulation (HD-tACS) with varying parameters on resting-state brain activity in patients with schizophrenia experiencing auditory hallucinations.

Official title: Frequency- and Intensity-Dependent After-Effects of High-Definition Transcranial Alternating Current Stimulation on Resting-State Electroencephalography in Patients With Auditory Hallucinations and Healthy Controls

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

36

Start Date

2025-12-05

Completion Date

2026-02-15

Last Updated

2026-09-01

Healthy Volunteers

Yes

Interventions

DEVICE

high-definition transcranial alternating current stimulation(HD-tACS)

The active intervention consists of high-definition transcranial alternating current stimulation (HD-tACS) delivered using a 4×1 ring configuration (one center electrode surrounded by four return electrodes) over the personalized left or right temporal lobe. The return electrodes deliver one-quarter of the central electrode current with opposite polarity. Stimulation is administered for 90 seconds per condition, with the frequency and current intensity set according to the experimental protocol. A 10-second ramp-up and a 5-second ramp-down period are included in each stimulation condition. The stimulus waveform is sinusoidal. Stimulation is delivered using saline-soaked sponge electrodes. Electrode impedance is maintained below 10 kΩ throughout the stimulation session.

DEVICE

sham high-definition transcranial alternating current stimulation(HD-tACS)

The sham intervention consists of high-definition transcranial alternating current stimulation (HD-tACS) delivered using a 4×1 ring configuration (one center electrode surrounded by four return electrodes) over the personalized left or right temporal lobe. The return electrodes deliver one-quarter of the central electrode current with opposite polarity. To mimic the sensory experience of active stimulation, the sham condition includes a 10-second ramp-up and a 5-second ramp-down period at 0.4 mA and 140 Hz, with no current delivered during the intervening 90-second period.

Locations (1)

Fuyang Mental Heath Center

Fuyang, China