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Opioid-Free Versus Opioid-Based Anesthesia in Modified Radical Mastectomy
Sponsor: Muhammad Fiqhi Amiruddin
Summary
This randomized controlled trial compares opioid-free anesthesia combined with pectoral nerve block (PECS I and II) with opioid-based anesthesia in patients undergoing modified radical mastectomy. The study evaluates postoperative CD4+ T-cell counts as a marker of cellular immune response, as well as postoperative pain intensity and nausea and vomiting. Twenty-eight patients were randomly assigned to receive either opioid-free anesthesia with PECS I and II block or opioid-based anesthesia with fentanyl. CD4+ T-cell counts were assessed before and 24 hours after surgery, while postoperative pain was assessed at 2, 6, 12, and 24 hours after surgery.
Official title: A Randomized Controlled Trial Comparing Opioid-Free Anesthesia With Pectoral Nerve Block and Opioid-Based Anesthesia in Patients Undergoing Modified Radical Mastectomy
Key Details
Gender
FEMALE
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
28
Start Date
2026-05-03
Completion Date
2026-07-30
Last Updated
2026-09-02
Healthy Volunteers
No
Conditions
Interventions
Pectoral Nerve Block (PECS I and II)
Ultrasound-guided pectoral nerve blocks (PECS I and II) performed before induction of general anesthesia.
Dexmedetomidine
Dexmedetomidine-based opioid-free anesthetic regimen administered according to the study protocol.
Fentanyl
Fentanyl-based opioid anesthesia administered according to the study protocol.
Locations (1)
Jl. Perintis Kemerdekaan Km. 10, Makassar 90245, Indonesia
Makassar, South Sulawesi, Indonesia