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The Impact of Exercise on Irisin-BDNF Regulation in Obstructive Sleep Apnea
Sponsor: National Cheng-Kung University Hospital
Summary
The goal of this clinical trial is to learn whether aerobic exercise can improve sleep and nervous system regulation in adults with mild to moderate obstructive sleep apnea (OSA). The study will also examine whether exercise changes blood markers related to inflammation and brain health. The main questions this study aims to answer are: 1. Does four weeks of aerobic exercise change blood levels of irisin, brain derived neurotrophic factor (BDNF), and markers related to inflammation? 2. Does aerobic exercise improve sleep apnea, heart rate variability, cognitive function, daytime sleepiness, sleep quality, and daily functioning? Researchers will compare an aerobic exercise group with a sleep education group to determine whether adding regular aerobic exercise provides additional benefits for people with mild to moderate OSA. Participants will be randomly assigned to one of two groups. Participants in the aerobic exercise group will: 1. Receive sleep education. 2. Complete four weeks of supervised treadmill exercise, three to five times per week. Each session will last about 45 to 60 minutes. Exercise intensity will be adjusted to each participant's heart rate and physical condition. Participants in the comparison group will: 1. Receive sleep education about OSA, common symptoms, treatment options, and healthy sleep habits. 2. Practice the recommended healthy sleep habits at home during the four-week study period. Participants in both groups will complete assessments before and after the four-week study period. These assessments will include an overnight sleep study, blood tests, heart rate measurements, cognitive tests, and questionnaires about daytime sleepiness, sleep quality, and daily functioning.
Official title: The Impact of Exercise on Irisin-Brain-Derived Neurotrophic Factor Regulation in Obstructive Sleep Apnea-Related Neuroinflammation: From Animal Model to Clinical Study
Key Details
Gender
All
Age Range
20 Years - 68 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2026-09-01
Completion Date
2030-12-31
Last Updated
2026-09-02
Healthy Volunteers
No
Conditions
Interventions
Supervised Aerobic Exercise
Participants will receive a 4-week supervised treadmill aerobic exercise program, performed 3-5 times per week for approximately 45-60 minutes per session. Exercise intensity will be individualized using heart rate reserve and progressively adjusted during the intervention. Each session will include warm-up, aerobic exercise, and cool-down periods.
Sleep Hygiene Education
Participants will receive a 20-30-minute sleep education session covering basic information about obstructive sleep apnea, common symptoms, treatment options, and sleep hygiene principles. Participants will be instructed to practice the recommended sleep hygiene strategies at home during the 4-week study period.
Locations (1)
National Cheng Kung University Hospital
Tainan, Taiwan