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Behavioral Activation for Cancer-Related Fatigue After Breast Cancer Surgery
Sponsor: Huaidong Cheng
Summary
Cancer-related fatigue is common after breast cancer surgery and may persist during adjuvant treatment and early survivorship. This randomized controlled trial evaluated whether an 8-week graded behavioral activation intervention could reduce cancer-related fatigue in women with stage I-III breast cancer after surgery. Participants were randomly assigned in a 1:1 ratio to behavioral activation plus care as usual or care as usual alone. Assessments were conducted at baseline, Week 4, and Week 8. The primary outcome was cancer-related fatigue measured with the revised Piper Fatigue Scale (PFS-R). Secondary outcomes included anxiety, depressive symptoms, global health status/quality of life, and heart rate variability. Prespecified systemic inflammatory biomarkers derived from complete blood counts included the neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII).
Official title: Behavioral Activation for Cancer-Related Fatigue After Breast Cancer Surgery: A Randomized Controlled Trial
Key Details
Gender
FEMALE
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
114
Start Date
2025-05-01
Completion Date
2025-12-31
Last Updated
2026-09-02
Healthy Volunteers
No
Conditions
Interventions
Behavioral Activation
A structured 8-week behavioral intervention consisting of eight weekly individual sessions of approximately 15-30 minutes. Core components included activity monitoring, values-based goal setting, graded activity scheduling, identification of inactivity and avoidance patterns, review of barriers, and maintenance planning.
Care as Usual
Routine oncology care and health education provided according to clinical needs and institutional practice.
Locations (1)
Shenzhen Hospital of Southern Medical University
Shenzhen, Guangdong, China