Clinical Research Directory

Inclusion Criteria: * Age ≥18, male or female; * Patients with respiratory failure and high Paco2, PH \< 7.35； * Researchers believe that this product is beneficial for patients undergoing treatment, such as patients with invasive ventilator weaning difficulty, large airway obstruction, etc； * Patients or guardians provided written informed consent voluntarily. Exclusion Criteria: * Oxygenation index \<80mmHg; * Intracranial hemorrhage or severe irreversible brain injury; * Thrombocytopenia; * Patients with malignant tumors (expected survival time \<1 year); * patients unable to receive systemic anticoagulation; * Obesity: BMI\>40kg/m2; * Those with a history of mental illness who were unable to cooperate in completing the trial; * During pregnancy and lactation; * Patients with allergic or severe allergic constitution to the test equipment; * Participated in other interventional device clinical trials within 3 months before this trial * Those who were deemed unsuitable to participate in the trial by the investigators.