Clinical Research Directory

Inclusion Criteria: All * Normal screening bloodwork. * Adequate arterial access for placement of an arterial line and blood sampling per study protocol. OUD Participants: * Diagnosis of opioid use disorder (OUD) according to DSM-5 criteria. * Actively seeking treatment for OUD. * Willingness to initiate opioid agonist therapy (OAT) with buprenorphine. Healthy Controls: * Good general physical health. * No current or past diagnosis of any psychiatric or substance use disorders. Exclusion Criteria: All * Any current major medical condition that, in the opinion of the Principal Investigator, poses a risk for PET procedures. * Prior participation in research studies within the past year that would result in cumulative radiation exposure exceeding annual limits. * Presence of ferromagnetic metal in the body, pacemaker, or other contraindications to MRI. * Positive pregnancy test or current lactation. * History of neurological conditions, including stroke or seizure disorders. OUD Participants * Current or past diagnosis of a serious psychiatric disorder. * Current diagnosis of any substance use disorder other than nicotine or opioids. * Use of any substances within the past 30 days. * Current use of SSRIs or benzodiazepines or use within the past 30 days. * Previous enrollment in the main study. Healthy Controls: * Current or past diagnosis of any psychiatric disorder. * Current diagnosis of any substance use disorder (excluding nicotine). * Use of any substances within the past 30 days.