Clinical Research Directory

Inclusion Criteria: * Signed informed consent. * Female participant aged 18-35 years. * Diagnosis of infertility requiring IVF/ICSI, including unexplained infertility or mild male factor infertility. * BMI 18-30 kg/m². * AMH ≥2.5 ng/mL. * AFC ≥12. * Basal FSH \<8 IU/L. * Ovaries accessible for transvaginal retrieval. * Willing to undergo serial unstimulated TVORs with adaptive retrieval timing. * Willing to undergo CAPA-IVM, ICSI, blastocyst culture, PGT-A, embryo vitrification/accumulation, and single euploid embryo transfer. * Willing to undergo serial ultrasound and endocrine monitoring. * Willing and able to comply with study procedures and follow-up. Exclusion Criteria: * Prior ovarian surgery. * Ovarian endometrioma. * Inaccessible ovaries. * Significant uterine factor expected to compromise implantation, pregnancy, or live birth. * Significant medical comorbidity that would increase risk of TVOR, pregnancy, or study participation. * AMH \<2.5 ng/mL. * AFC \<12. * Basal FSH ≥8 IU/L. * BMI \<18 or \>30 kg/m². * Current smoking or nicotine use within 3 months of screening. * Active pelvic infection, untreated STI, or acute urinary tract infection. * Contraindication to transvaginal oocyte retrieval, anesthesia/sedation, pregnancy, or antibiotic prophylaxis. * Known chromosomal abnormality in the participant or sperm source that would confound study outcome assessment. * Severe male factor infertility requiring surgical sperm retrieval, unless specifically permitted by the final protocol. * Recent exposure to teratogenic radiation, drugs, or toxins. * Current participation in another interventional clinical trial that may confound outcomes. * Previous participation in the CARE study.