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Clinical & Biochemical Evaluation of Antioxidant Vs. Chlorhexidine as an Adjunctive to Non-Surgical Treatment of Stage II-grade B Periodontitis
Sponsor: Al-Azhar University
Summary
This randomized clinical trial aims to evaluate and compare the clinical and biochemical effects of an antioxidant agent and chlorhexidine when used as adjuncts to non-surgical periodontal therapy in patients with Stage II Grade B periodontitis. Eligible participants will receive scaling and root planing (SRP) and will be randomly assigned to either the antioxidant or chlorhexidine treatment group. Clinical periodontal parameters, including plaque index, gingival index, probing depth, and clinical attachment level, will be assessed at baseline and follow-up visits. Biochemical analysis of inflammatory markers, including tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1), will be performed to evaluate the inflammatory response to treatment. The study aims to determine whether antioxidant therapy provides comparable or superior benefits to chlorhexidine as an adjunct to non-surgical periodontal treatment.
Official title: Clinical & Biochemical Evaluation of Antioxidant Vs. Chlorhexidine as an Adjunctive to Non-Surgical Treatment of Stage II-grade B Periodontitis.
Key Details
Gender
All
Age Range
25 Months - 40 Months
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2025-12-01
Completion Date
2027-07-01
Last Updated
2026-09-03
Healthy Volunteers
No
Conditions
Interventions
Perioscience Gel
Local application of Perioscience antioxidant gel into periodontal pockets following scaling and root planing (SRP).
High Cure Chlorhexidine Gel
Local application of High Cure chlorhexidine gel into periodontal pockets following scaling and root planing (SRP).
High Cure Chlorhexidine Gel + Perioscience Gel
Local application of both High Cure chlorhexidine gel and Perioscience gel into periodontal pockets following scaling and root planing (SRP).
Scaling and Root Planing (SRP)
Conventional full-mouth scaling and root planing performed using ultrasonic and hand instruments.
Locations (1)
Alazhar University
Cairo, Cairo Governorate, Egypt