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NOT YET RECRUITING
NCT07802223
NA

Closed-loop tTIS Targeted of the Nac as an Intervention for MUD Patients

Sponsor: Shanghai Mental Health Center

View on ClinicalTrials.gov

Summary

Closed-loop transcranial temporal interference stimulation (tTIS) targeting the nucleus accumbens may modulate abnormal neural responses to drug-related cues in individuals with methamphetamine use disorder (MUD), thereby reducing drug craving and improving cognitive and behavioral control. Stimulation will be delivered in real time according to each patient's cue-induced response time.

Official title: Closed-loop Transcranial Temporal Interference Stimulation Targeted of the Nucleus Accumbens as an Intervention for Methamphetamine Use Disorder Patients

Key Details

Gender

All

Age Range

18 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

50

Start Date

2026-09-01

Completion Date

2026-11-01

Last Updated

2026-09-03

Healthy Volunteers

No

Interventions

DEVICE

Temporal Interference Stimulation

Each session will comprise 240 trials, during which stimulation may be triggered up to 10 times according to the participant's cue-reactivity state. Each stimulation will consist of a 5-s current ramp-up, 30 s of continuous stimulation, and a 5-s current ramp-down. The intervention will be administered once daily for five consecutive days.

DEVICE

Shame

The stimulation parameters-including frequency, current intensity, and duration-are identical to those in the active group. However, the sham stimulation mode is activated on the device, resulting in consist of a 5-s current ramp-up, but 0 s of continuous stimulation during the stimulation.

Locations (1)

Shanghai Mental Health Center

Shanghai, Shanghai Municipality, China