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Postprandial Glucose Kinetics After Carbohydrate Restriction
Sponsor: Azienda Ospedaliero, Universitaria Pisana
Summary
The goal of this study is to test whether a low-carbohydrate diet (LCD), comparred with a Mediterranean diet (MED) producing similar weight loss, differentially affects fasting and postprandial glucose metabolism in individuals with overweight and dysglycemia. The main questions it aims to answer are: * Is oral glucose absorption delayed or reduced after chronic carbohydrate restriction? * Is insulin sensitivity differentially affected? Participants will follow 4 weeks of LCD and 4 weeks of MED, in a random order, separated by a 4-week washout. After each intervention, participants will undergo a dual-tracer 75-g oral glucose tolerance test.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
29
Start Date
2019-11-01
Completion Date
2026-08-30
Last Updated
2026-09-03
Healthy Volunteers
No
Interventions
Low-carbohydrate diet
A 4-week diet providing 20% of total energy from carbohydrates, 55% from fat, and 25% from protein, with an energy restriction of 200-400 kcal/day relative to basal metabolic rate.
Mediterranean Diet
A 4-week diet providing 50% of total energy from carbohydrates, 30% from fat, and 20% from protein, with an energy restriction of 200-400 kcal/day relative to basal metabolic rate.
Locations (1)
Laboratory of Metabolism, Nutrition and Atherosclerosis, University of Pisa
Pisa, PI, Italy