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ALDH2 rs671, Alcohol Use, and Health Education in University Students
Sponsor: National Taiwan University Hospital
Summary
Alcohol intolerance is common in East Asian populations and is strongly influenced by the rs671 variant in the ALDH2 gene. This study examined the associations of ALDH2 genotype with drinking behavior and alcohol-related reactions among Taiwanese university students. Participants with previous alcohol exposure underwent rs671 genotyping and received their individual genotype results together with the same standardized health education materials about alcohol intolerance and related health risks. Drinking behavior, knowledge, and attitudes were assessed before and one month after the intervention. The study also evaluated whether facial flushing and rapid heartbeat could help identify ALDH2 deficiency. Changes over the one-month period were evaluated overall and by genotype group.
Official title: Investigation of the Relationship Between rs671 Polymorphism and Attitudes and Behaviors Toward Drinking and Effectiveness of Health Education
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
622
Start Date
2022-01-09
Completion Date
2022-05-24
Last Updated
2026-09-03
Healthy Volunteers
Yes
Interventions
Individual ALDH2 Genotype Feedback
Participants underwent ALDH2 rs671 genotyping and received an individual report indicating their rs671 genotype (GG, GA, or AA) and corresponding ALDH2 metabolic status. No individualized health education was provided based on genotype.
Standardized Alcohol Health Education
All participants received the same standardized health education materials concerning alcohol metabolism, symptoms of alcohol intolerance, and health risks associated with alcohol use and ALDH2 deficiency. The educational content was not individualized according to genotype.
Locations (1)
National Taiwan University
Taipei, Taiwan