Clinical Research Directory

Inclusion Criteria: * having been previously included and completed the ENVOL study * Ability and willingness to provide informed consent * Having a valid health insurance in France In glaucoma group : * Glaucomatous optic neuropathy, being able to be graded by the vertical C/D ratio * Open angle on gonioscopy in a dark-room testing according to Shaffer's classification (grade 3 or grade 4) * Visual field impairement (at least one of the following) : * 3 adjacent points with at least 5dB loss * one point with a loss of 10dB * a difference of at least 10 dB for 2 adjacent points on either side of the horizontal meridian of the nasal visual field * Mini Mental State Score of at least 28 In control group : * No personal or family history of glaucoma or ocular hypertension (IOP \> 21 mmHg) * Open angle on gonioscopy in a dark-room testing according to Shaffer's classification (grade 3 or grade 4) * Intraocular pressure of ≤ 21 mmHg * Absence of glaucomatous neuropathy * Normal visual field Exclusion Criteria: * Inability/unwillingness to provide informed consent * Other causes of ocular hypertension (trauma, uveitis) * Non-glaucomatous optic neuropathy (infectious, inflammatory, compressive, ischemic) * Unreliable visual field (\>15% false positives, \>33% false negatives or \>20% loss of fixation) * Severe corneal pathology preventing access to fundus, visual field testing or altering ocular tonometry * Contraindications to MRI testing (pacemakers or neurosensory stimulators, cochlear implants, ferromagnetic foreign bodies, claustrophobia) * Patients under guardianship or other form of legal protection