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NOT YET RECRUITING
NCT07803458
NA

Attention-based Binocular Training for Impaired Stereopsis (BRAVE)

Sponsor: Centre for Eye and Vision Research

View on ClinicalTrials.gov

Summary

This study evaluates a novel attention-based binocular visual search training paradigm designed to improve stereopsis (stereo vision) in individuals with impaired binocular vision. Disruptions in balanced binocular input, such as from strabismus or anisometropia, often lead to deficient stereo vision, causing daily visuomotor limitations. While traditional therapies focus on monocular acuity, they frequently fail to restore stereopsis, especially in adults. The investigators propose a unique dichoptic visual search training method that embeds binocular disparity inside an attention-demanding task, encouraging cooperative binocular integration. Participants aged 18-39 with impaired stereopsis will be randomly assigned in a 1:1 ratio to either the active training group (disparity-embeded task) or the active control group (identical task with zero disparity). Both groups complete 5 training sessions over 5-6 weeks. Assessments will occur at baseline, immediately post-training, and at a 12-week follow-up. The primary objective is to determine if the active training group shows significantly greater improvements in local stereoacuity compared to the control group.

Official title: Binocular Recovery Through Attention-based Visual Enhancement: A Randomized Controlled Trial (BRAVE Trial)

Key Details

Gender

All

Age Range

18 Years - 39 Years

Study Type

INTERVENTIONAL

Enrollment

56

Start Date

2026-11-01

Completion Date

2029-03-30

Last Updated

2026-09-03

Healthy Volunteers

Yes

Interventions

BEHAVIORAL

Attention-Guided Dichoptic Visual Search Training

A computer-based dichoptic training paradigm in which visual stimuli are presented separately to each eye under balanced interocular contrast . Participants search for conjunction-defined targets across 5 sessions (5 blocks of 192 trials per session). The target stimulus is uniquely paired with crossed binocular disparity to provide depth-based attentional guidance, with target disparity adaptively reduced based on search performance.

BEHAVIORAL

Zero-Disparity Dichoptic Visual Search Task

An active control dichoptic task identical in visual stimuli, trial structure (5 sessions; 5 blocks of 192 trials per session), and interocular contrast balancing to the training arm, but presented with zero binocular disparity (all stimuli appear in the same depth plane without depth cues).

Locations (2)

Centre for Eye and Vision Research Limited

Hong Kong, Hong Kong SAR, Hong Kong

The Hong Kong Polytechnic University

Hong Kong, Hong Kong SAR, Hong Kong