Clinical Research Directory

Inclusion Criteria: * ASA I and ASA II. * Age (35yrs - 75yrs). * Patients undergoing open colorectal cancer surgery. * Sex: Both sexes. Exclusion Criteria: * Renal impairment (Glomerular Filtration Rate \< 60 ml\\min). * Severe cardiac dysfunction (Ejection fraction ≤ 30% or clinical signs and symptoms of reduced left ventricular ejection fraction), preoperative bradycardia (HR \< 50 bpm) and atrioventricular block (first, second and third degree). * Allergy to study drug (MgSO4). * Patient refusal to precipitate in this study. * Autoimmune disorders (eg: rheumatoid arthritis, multiple sclerosis and lupus), congenital and acquired immunodeficiency. * Previous / current immunomodulatory therapy. * Emergency condition (eg: obstruction or perforation in colorectal cancer). * Postoperative complications altering inflammatory response (eg: infection, anastomotic leak). * Duration of operation \> 5 hours. * Cognitive impairment (eg: Dementia) and other psychiatric disorders by history. * Body mass index less than 18 or greater than 30 kg/m².