Clinical Research Directory
Browse clinical research sites, groups, and studies.
Comparative Immunologic Mechanisms and Microbiome Interactions Following Different Influenza Vaccine Formulations in Older Adults
Sponsor: Korea University Guro Hospital
Summary
This prospective, randomized, open-label clinical study aims to evaluate the immunogenicity and underlying immune mechanisms of different influenza vaccine formulations in adults aged ≥65 years. Additionally, the study investigates the role of the gut microbiome in modulating vaccine-induced immune responses and durability.
Key Details
Gender
All
Age Range
65 Years - Any
Study Type
INTERVENTIONAL
Enrollment
121
Start Date
2025-10-25
Completion Date
2026-08-31
Last Updated
2026-09-04
Healthy Volunteers
Yes
Interventions
Standard-Dose Influenza Vaccine
0.5 mL intramuscular injection, single dose
MF59-Adjuvanted Influenza Vaccine
0.5 mL intramuscular injection, single dose
High-Dose Influenza Vaccine
0.7 mL intramuscular injection, single dose
Locations (1)
Korea University Guro Hospital
Seoul, Seoul, South Korea