Clinical Research Directory

Circulating Muscle-specific microRNAs and Renal, Nutritional and Inflammatory Biomarkers of Skeletal Muscle Loss During the First 18 Months After Laparoscopic Sleeve Gastrectomy

Sponsor: General Committee of Teaching Hospitals and Institutes, Egypt

Summary

Metabolic and bariatric surgery produces substantial and durable weight loss, but a considerable proportion of that loss is not adipose tissue. Pooled estimates indicate approximately 8 kg of fat-free mass and 3 kg of skeletal muscle mass are lost within twelve months, with more than half occurring in the first three months. No validated circulating biomarker of skeletal muscle loss exists for this population, and body composition can currently be assessed only intermittently. Muscle-specific microRNAs (myomiRs) are mechanistically plausible candidates but have never been measured in patients undergoing metabolic and bariatric surgery. This study will characterise the trajectory of skeletal muscle loss over eighteen months after laparoscopic sleeve gastrectomy and evaluate, as exploratory analyses, whether circulating myomiRs and routinely accessible renal, nutritional and inflammatory measures track that trajectory.

Official title: Circulating Muscle-specific microRNAs and Renal, Nutritional and Inflammatory Biomarkers of Skeletal Muscle Loss During the First 18 Months After Laparoscopic Sleeve Gastrectomy: Protocol for a Prospective Observational Cohort Study

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