Clinical Research Directory

Inclusion Criteria: 1. Patients aged between 18 and 65 years. 2. Both genders. 3. Moderate to severe traumatic brain injury with Glasgow coma scale scores between 4 and 12 on admission, with no need for surgical operations. 4. Requiring mechanical ventilation and continuous sedation for more than 24 hours. Exclusion Criteria: 1. History of severe hepatic or renal failure. 2. Known hypersensitivity to propofol or dexmedetomidine. 3. Pre-existing severe bradycardia (heart rate less than 50 bpm) or advanced heart block. 4. Confirmed brain death or moribund patients. 5. Pregnancy or lactation. 6. Preexisting neurological disease affecting GCS interpretation. 7. General anesthesia 24 hours prior to or planned after the start of study drug infusion. 8. Serious central nervous system pathology (acute stroke, severe dementia, uncontrolled seizures). 9. Patients with compromised cardiac diseases or heart block. 10. Any patients with ocular trauma, orbital fractures, glaucoma, or history of optic nerve disease.