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Reproducibility of Photobiomodulation Induced Changes in Local Skin Blood Flow in Healthy Subjects
Sponsor: Norwegian University of Science and Technology
Summary
This study investigated whether near-infrared photobiomodulation (PBM), a non-invasive light therapy, can consistently increase blood flow in the skin of healthy adults. Participants attended two identical study sessions in which they received both active PBM treatment and a placebo treatment using the same device with the light turned off. A subgroup of participants also completed a heat-control session to determine whether any changes in blood flow were caused by the light itself or by heat from the device.
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
16
Start Date
2022-04-01
Completion Date
2023-10-01
Last Updated
2026-09-15
Healthy Volunteers
Yes
Conditions
Interventions
Near-infrared photobiomodulation (NIR PBM)
Near-infrared photobiomodulation delivered using a modified Anodyne® Therapy System (Model 120). Device parameters included 890 nm wavelength, irradiance of 5.1 mW/cm², radiant exposure of 4.6 J/cm² and total radiant energy of 35.9 J. The intervention consisted of ten cycles of 3 minutes ON followed by 2-minute OFF intervals.
Sham Placebo
Identical device placement and treatment schedule with the LEDs deactivated. No near-infrared light was delivered.
Control (heat)
The modified device was wrapped in aluminium foil to prevent near-infrared light from reaching the skin while allowing conductive heat transfer. The protocol was otherwise identical to the active intervention.
Locations (1)
NTNU, St Olavs Hospital
Trondheim, Norway