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Evaluation of the Efficacy of Topical Application of Liquid Nitrogen and Ascorbic Acid in Treatment of Gingival Pigmentation
Sponsor: Al-Azhar University
Summary
Aim of study The present study will be designed to evaluate the clinical and histomorphometric outcomes of using topical liquid nitrogen and topical ascorbic acid in gingival depigmentation. Primary outcome: • Clinical severity and extension of gingival pigmentation. Secondary outcome: • Histologic assessment of the melanin forming cells.
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-09-01
Completion Date
2027-04
Last Updated
2026-09-09
Healthy Volunteers
No
Interventions
Topical application of ascorbic acid for treatment of gingival pigmentation
topical application of ascorbic acid (non surgical technique ) for treatment of gingival pigmentation
Topical application of liquid nitrogen for treatment of gingival pigmentation
Topical application of liquid nitrogen (non surgical technique ) for treatment of gingival pigmentation
Treatment of gingival pigmentation by surgical technique
conventional technique for treatment of gingival pigmentation
Locations (1)
Faculty of dental medicine, Alazhar university, Assiut branch
Asyut, Asyut Governorate, Egypt