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Lactobacillus Acidophilus and Inulin for Cognitive Impairment in Obesity
Sponsor: Anahuac University
Summary
This randomized crossover clinical trial aims to evaluate the effect of a synbiotic containing Lactobacillus acidophilus and inulin on cognitive function in adults with obesity and mild cognitive impairment. Forty participants aged 30-40 years will be randomly assigned to two groups. Participants will receive either the synbiotic intervention or a control preparation, followed by crossover to the alternate intervention. Cognitive function will be evaluated using the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), and Memory Alteration Test (M@T). Fecal butyrate and Lactobacillus acidophilus, as well as serum inflammatory cytokines and BDNF, will also be assessed to explore potential mechanisms involving the gut-brain axis.
Official title: Effect of Lactobacillus Acidophilus Combined With Inulin on Cognitive Impairment in Patients With Obesity
Key Details
Gender
All
Age Range
30 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-11-01
Completion Date
2027-06-01
Last Updated
2026-09-10
Healthy Volunteers
No
Conditions
Interventions
Synbiotic (Lactobacillus acidophilus LA-5 and Agave Inulin)
Participants will receive 2 g of Lactobacillus acidophilus (4 × 10⁹ CFU) plus 7 g of agave inulin, combined with 20 g of a powder containing almond, cinnamon, vanilla, and oats, dissolved in water and administered once daily for 12 weeks.
Locations (1)
Universidad Anahuac
Huixquilucan, State of Mexico, Mexico