Clinical Research Directory

Inclusion Criteria: * Aged 18 to 75 years. * Histologically confirmed squamous cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of the cervix; FIGO 2018 stage IB3 or IIA2, or carefully selected stage IIB or IIIC1r disease following multidisciplinary team evaluation, with a maximum primary tumor diameter ≥4 cm. For participants with stage IIB or IIIC1r disease, PET/CT or an equivalent staging examination must exclude para-aortic lymph node metastasis and distant metastasis, and definitive concurrent chemoradiotherapy must remain feasible if neoadjuvant treatment is ineffective. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Able to provide adequate tumor tissue for biomarker testing, defined as at least 18 qualified tissue sections. * No prior surgery for cervical cancer, except staging procedures, and no prior radiotherapy, chemotherapy, systemic anticancer therapy, investigational therapy, or immunotherapy for cervical cancer. * At least one measurable lesion according to RECIST version 1.1, defined as a tumor lesion with a longest diameter ≥10 mm on CT or a lymph node with a short-axis diameter ≥15 mm on CT. * Estimated life expectancy ≥6 months. * No primary or metastatic central nervous system disease. * Adequate major organ function, meeting all of the following criteria: * No blood or blood-product transfusion within 14 days before assessment; * Absolute neutrophil count (ANC) ≥1.5 × 10⁹/L; * Platelet count ≥80 × 10⁹/L; * Hemoglobin ≥9 g/dL; * Total bilirubin \<1.5 × upper limit of normal (ULN); * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 × ULN; * Serum creatinine ≤1.5 × ULN, or creatinine clearance ≥40 mL/min calculated using the Cockcroft-Gault formula. * Positive for high-risk human papillomavirus (HPV) DNA. * Written informed consent provided and willingness to comply with protocol-required follow-up. Exclusion Criteria: * Considered unsuitable for participation in the study by the investigator. * Known hypersensitivity or allergy to any study drug. * Any active, known, or suspected autoimmune disease, including but not limited to interstitial pneumonitis, uveitis, enteritis, hepatitis, arthritis, nephritis, hypophysitis, hyperthyroidism, or hypothyroidism; vitiligo; or asthma requiring medical intervention with bronchodilators. * Congenital or acquired immunodeficiency, including HIV infection, hepatitis B, or hepatitis C. * Prior treatment with PD-1 and/or PD-L1 inhibitors, CTLA-4 antibodies, or other agents targeting immune-regulatory receptors. * Current use of immunosuppressive agents. Patients in a stable condition who do not require systemic immunosuppressive therapy may be eligible. * Long-standing unhealed wounds or fractures; major surgery, severe traumatic injury, fracture, or ulcer within 4 weeks before initiation of study treatment. * Poorly controlled cardiac symptoms or cardiovascular disease, including New York Heart Association (NYHA) class III-IV heart failure or left ventricular ejection fraction (LVEF) \<50%; abnormal coagulation function defined as INR \>1.5 or APTT \>1.5 × ULN with a bleeding tendency; or an arterial or venous thromboembolic event within 6 months before the first dose of study treatment. * Symptomatic ascites, pleural effusion, or pericardial effusion requiring therapeutic puncture or drainage. Patients whose pleural or pericardial effusion remains stable for at least 2 weeks after drainage before the first dose of study treatment may be eligible. * Central nervous system metastases. * History of another malignancy, except for cured basal cell carcinoma of the skin or cervical carcinoma in situ. * Pregnant or breastfeeding women. * History of psychotropic drug abuse with inability to discontinue such use, or presence of a psychiatric disorder.