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A Comparative Study of Normalized Residual Activity and Standard Parameters in 99mTc-DTPA Diuretic Renography:
Sponsor: Assiut University
Summary
The present study aims to compare the diagnostic performance of Normalized Residual Activity (NORA) with conventional renographic parameters obtained from 99mTc-diethylenetriamine pentaacetic acid (99mTc-DTPA) diuretic renography in the evaluation of patients with suspected urinary tract obstruction. The study seeks to determine whether NORA provides superior diagnostic accuracy and specificity for differentiating true urinary tract obstruction from non-obstructive dilatation, thereby improving the interpretation of diuretic renography and supporting appropriate clinical decision-making.
Official title: Improving Obstruction Diagnosis in 99mTc-DTPA Diuretic Renography: A Comparative Study of Normalized Residual Activity and Standard Parameters
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
57
Start Date
2026-08-26
Completion Date
2028-08-01
Last Updated
2026-09-10
Healthy Volunteers
Not specified
Conditions
Interventions
99m Tc-DTPA
All patients will undergo 99mTc-DTPA diuretic renography according to the standardized departmental protocol. Patients will receive adequate oral or intravenous hydration before imaging. Following intravenous administration of 99mTc-DTPA, dynamic renal scintigraphy will be performed using a dual-head gamma camera equipped with a low-energy high-resolution collimator. Furosemide (1" mg/kg" for pediatrics, or a standard 40" mg" dose for adults) will be injected intravenously at 10 minutes post-radiopharmaceutical injection (F+10 protocol) Dynamic imaging will continue for an additional 20minutes. Patients will be instructed to void at the completion of dynamic imaging after positioning in the upright position for five minutes to promote additional drainage of tracer from the collecting system, followed by acquisition of post-void images.
Furosemide
Furosemide (1 mg/kg for pediatrics, or a standard 40 mg dose for adults) will be injected intravenously at 10 minutes post-radiopharmaceutical injection (F+10 protocol) Dynamic imaging will continue for an additional 20minutes.