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Latent Infection Freshmen Tracking for Tuberculosis
Sponsor: Affiliated Hospital of Nantong University
Summary
The goal of this study is to learn whether taking short-course preventive treatment in high school and college freshmen with strong positive tuberculosis (TB) skin tests can safely and effectively protect them from developing active TB over a 3-to-4-years period. Main question: Does taking short-course preventive treatment reduce the risk of active TB in freshmen who have strong positive TB skin tests? All freshmen across 26 schools in Meishan City, Sichuan Province, China were screened for TB. Among them, the students with strong positive skin tests (indicating latent TB infection) and no active disease entered the study. Students voluntarily chose to either take a 3-month short-course preventive treatment under campus medical supervision or receive routine health observation without medication. Researchers tracked all participants for 3 to 4 years to monitor who developed active TB and evaluate the treatment's safety and effectiveness.
Official title: Real-World Implementation and Effectiveness of Tuberculosis Preventive Treatment in School Health Services in China
Key Details
Gender
All
Age Range
14 Years - 24 Years
Study Type
INTERVENTIONAL
Enrollment
3000
Start Date
2022-08-15
Completion Date
2029-08-31
Last Updated
2026-09-10
Healthy Volunteers
Yes
Interventions
tuberculosis preventive treatment
3HR Regimen: Isoniazid (INH) + Rifampin (RIF), once daily, 90 total doses (3 months); 3H2P2 Regimen: Isoniazid (INH) + Rifapentine (RPT), twice weekly, 24 total doses (3 months)
Locations (2)
Affiliated Hospital of Nantong University
Nantong, Jiangsu, China
Meishan Municipal Center for Disease Prevention and Control
Meishan, Sichuan, China