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Radiological Markers for PDA Management in Preterm Infants
Sponsor: Assiut University
Summary
The aim of this Randomized controlled trial is to determine whether Echo with Organ Doppler-guided management strategy for hemodynamically significant patent ductus arteriosus (hsPDA) improves the short-term outcomes compared with standard care in preterm neonates. the research question is Does the usage of new radiological markers minimize the hsPDA group and decrease the pharmacological management in order to decrease the side effects of the treatment ? Researchers will compare the Echo with Organ Doppler management group to the standard care group.
Official title: Novel Radiological Markers for PDA-Targeted Management in Preterm Infants: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
0 Hours - 96 Hours
Study Type
INTERVENTIONAL
Enrollment
88
Start Date
2027-01-01
Completion Date
2028-06
Last Updated
2026-09-10
Healthy Volunteers
No
Interventions
Organ doppler
Organ Doppler (Superior mesenteric artery (SMA) and Middle cerebral artery (MCA)). -Two arteries, one primary parameter: End-diastolic velocity (EDV). \*Definition of abnormal organ Doppler: Any abnormality in SMA or MCA (low EDV or ARDF) (Mifflin et al., 2026)
Echocardiography
Include a statement on hemodynamic significance based on 5 parameters: (Winners et al. (2023). 1. Diameter 2. Flow direction 3. Systolic and diastolic flow velocities 4. Indices of pulmonary over circulation 5. Left ventricular output - Plus, one parameter of left sided volume loading or left heart pressure loading, systemic shunt effect, doppler flow patterns in the systemic circulation.