Clinical Research Directory

Inclusion Criteria: * Healthy males aged 30 to 65 years inclusive * BMI of 18.0 to 35.0 kg/m2 inclusive * Regular bowel movements (i.e. average stool production of ≥1 and ≤3 stools per day) Exclusion Criteria: * Serious adverse reaction or serious hypersensitivity to any drug or formulation excipients * Presence or history of clinically significant allergy requiring treatment * History of clinically significant cardiovascular, renal, hepatic, respiratory, dermatological or gastrointestinal disease, and neurological or psychiatric disorder * History of cholecystectomy or gall stones * History of GI surgery * Acute diarrhoea or constipation in the 7 days before the predicted Day 1 * Participants who do not have suitable veins for multiple venepunctures/cannulation * Clinically significant abnormal clinical chemistry, haematology, coagulation or urinalysis * Evidence of renal impairment at screening * Participants who have received any IMP in a clinical research study within the 90 days prior to Day 1 * Participants who have previously been administered IMP in this study * Radiation exposure exceeding 5 mSv in the last 12 months or 10 mSv in the last 5 years * Participants who have been administered IMP in an ADME study in the last 12 months * Donation of blood or plasma within the previous 3 months or loss of greater than 400 mL of blood * Use of any prescribed or non-prescribed medication including antacids, gastric pH modifying agents, analgesics, herbal remedies, vitamins and minerals within 2 weeks of dosing * Current smokers or known or suspected history of alcohol or drug abuse * Excessive intake of caffeine-containing drinks or food