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NOT YET RECRUITING
NCT07812792
PHASE2

Effect of Pentadecanoic Acid Supplementation on Red Blood Cell Health and Biological Aging in Healthy Older Adults

Sponsor: ReCellience15, Inc

View on ClinicalTrials.gov

Summary

This Phase II randomized, double-blind, placebo-controlled, parallel-group study will evaluate the effects of pentadecanoic acid (C15:0) supplementation on red blood cell (RBC) health and predicted biological age in healthy adults aged 55 years and older. A total of 93 participants will be randomized to receive 200 mg of C15:0, 300 mg of C15:0, or placebo daily for approximately 12 weeks. The primary objective is to assess the effect of C15:0 on red blood cell distribution width (RDW-CV), a marker of RBC health, compared with placebo. Secondary outcomes include measures of inflammation, hematologic and iron metabolism markers, circulating C15:0 levels, biological age-related biomarkers, sleep quality, fatigue, energy, and health-related quality of life. Safety and tolerability will also be evaluated throughout the study.

Official title: A Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Effects and Impacts of Supplemental Pentadecanoic Acid on Red Blood Cell Health and Activity and Predicted Biological Age in Healthy Older Adults

Key Details

Gender

All

Age Range

55 Years - Any

Study Type

INTERVENTIONAL

Enrollment

93

Start Date

2027-01

Completion Date

2027-06

Last Updated

2026-09-10

Healthy Volunteers

Yes

Interventions

DIETARY_SUPPLEMENT

Pentadecanoic Acid

Pentadecanoic acid is administered orally as capsules once daily with the participant's first meal for approximately 12 weeks (84 ± 2 days). Participants receive one daily dose consisting of three capsules. The 200 mg/day group receives two active capsules and one placebo capsule, while the 300 mg/day group receives three active capsules. Participants take their first dose in-clinic on Day 1 and continue daily dosing at home from Day 2 through the day before the end-of-study visit.

OTHER

Placebo

Placebo is administered orally as three matching placebo capsules once daily with the participant's first meal for approximately 12 weeks (84 ± 2 days). Placebo capsules are manufactured to match the active study product in physical appearance and packaging to maintain blinding.

Locations (1)

Apex Trials

Guelph, Ontario - on, Canada