Clinical Research Directory

Inclusion Criteria: * Be in general good health * Be willing and physically able to carry out all study procedures and be available at all times required for participation * Be able to fully understand and comply with the written and verbal instructions provided * Provide written informed consent * Be willing to attend all study visits * Agree to return study materials at the required visit(s) * Between the ages of 18-59 years * Be a non-smoker * Have a minimum of 20 'scorable' teeth (excluding 3rd molars) * Have an average plaque score of \>1.8 per Modified Plaque Index scoring with 3-6 hours of plaque accumulation * Have a gingival bleeding score of \>1 on a minimum of 50 gingival sites per Gingival Bleeding Index * Be a regular manual toothbrush user Exclusion Criteria: * Are pregnant or nursing per subject report * A medical or dental condition that would be unduly affected by participation in this study, per Investigator discretion * A medical condition requiring antibiotic pre-medication prior to dental appointments * Diagnosis of xerostomia * Oral or extra oral piercing that interferes with the ability to perform study procedures and/or clinical assessments in the mouth * Currently undergoing or requiring dental/periodontal treatment, or having had periodontal treatment in the six months preceding the study, where the subject's study participation could present an undue safety risk or obscure the evaluation of study endpoints, per Investigator/Examiner discretion * Oral surgery within the last 2 months * Currently using professionally dispensed bleaching products * A known allergy or sensitivity to products planned for use in this study * Unwilling to abstain from all other oral hygiene products other than those prescribed for the duration of the study * Participated in an oral care study within the previous 60 days * Employee or a relative of an employee of the Site clinical research department, dental school, or a dental products manufacturing, research or marketing firm * Dental student or dental professional * A cardiac pacemaker or implanted cardiac defibrillator * Insulin-Dependent Diabetes * Immunocompromised or Immune-impaired/suppressed. * Current use of antibiotic medications or use within 4 weeks of enrollment * Current use of prescription-dose anti-inflammatory medications or anticoagulants; (including aspirin \> 81 mg daily) * Presence of advanced periodontal disease or excessive gingival recession, per Investigator/Examiner discretion * Heavy deposits of calculus, either supragingival and/or subgingival, per Investigator/Examiner discretion * Extensive crown or bridge work and/or rampant decay, per Investigator/Examiner discretion * Presence of orthodontic bands, wires or brackets * A professional prophylaxis within 4 weeks of the study