Clinical Research Directory

Laparoscopic Falciform Ligament Flap Versus Omental Patch for Perforated Peptic Ulcers

Sponsor: Assiut University

Summary

Peptic ulcer perforation is a serious complication of peptic ulcer disease that requires urgent surgical treatment. The standard minimally invasive method is laparoscopic omental patch repair, in which a portion of the patient's greater omentum is placed over the ulcer perforation to seal the defect. However, in some patients, the omentum may be scarred, retracted, or unavailable due to prior surgery, and postoperative leakage can still occur. The falciform ligament, which is a well-vascularized tissue fold connecting the liver to the anterior abdominal wall, serves as an alternative tissue flap for ulcer closure. The purpose of this prospective randomized clinical trial is to compare the safety and efficacy of laparoscopic falciform ligament flap repair against conventional laparoscopic omental patch repair in adult patients with perforated gastric or duodenal peptic ulcers measuring 2 cm or less. Participants eligible for laparoscopic repair are randomly assigned during surgery to one of two groups: * Group A (Active Comparator): Undergoes laparoscopic omental patch repair (Graham technique). * Group B (Experimental): Undergoes laparoscopic pedicled falciform ligament flap repair. The primary objective is to determine whether the falciform ligament flap reduces or demonstrates comparable rates of postoperative repair-site leakage within 30 days after surgery. Secondary objectives include comparing operative duration, intra-operative blood loss, rates of conversion to open surgery, post-operative pain scores, length of hospital stay, 30-day morbidity and mortality, and endoscopic ulcer healing at 6 to 8 weeks of follow-up.

Official title: Laparoscopic Falciform Ligament Flap Versus Omental Patch Repair for the Treatment of Perforated Peptic Ulcers: A Prospective Randomized Clinical Trial

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