Clinical Research Directory
Browse clinical research sites, groups, and studies.
Efficacy of Palonosetron Plus Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Gynaecological Laparoscopic Surgery
Sponsor: Bangladesh Medical University
Summary
Postoperative nausea and vomiting (PONV) is a common complication after general anaesthesia, especially among female patients undergoing laparoscopic surgery. This randomized controlled trial evaluates whether combined palonosetron and dexamethasone is more effective than palonosetron alone in preventing postoperative nausea and vomiting after gynaecological laparoscopic surgery. Eligible patients will be randomized into two parallel groups. The intervention group will receive palonosetron plus dexamethasone, while the comparator group will receive palonosetron alone. Patients will be followed for 24 hours after surgery for incidence and severity of nausea and vomiting, rescue antiemetic requirement, adverse effects, patient satisfaction, and haemodynamic parameters.
Official title: Efficacy of Combined Palonosetron and Dexamethasone for Prevention of Post-operative Nausea and Vomiting in Patients Undergoing Gynaecological Laparoscopic Surgery
Key Details
Gender
FEMALE
Age Range
20 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
76
Start Date
2025-09-10
Completion Date
2026-05-30
Last Updated
2026-09-10
Healthy Volunteers
No
Conditions
Interventions
Palonosetron and Dexamethason
Participants receive palonosetron 0.075 mg IV combined with dexamethasone 5 mg IV before induction of general anaesthesia.
Palonosetron
Participants receive palonosetron 0.075 mg IV before induction of general anaesthesia.
Locations (1)
Bangladesh Medical University
Dhaka, Bangladesh