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Metabolic and Nutritional Responses to Acute High-intensity Interval Exercise Performed Under Hypoxic vs. Normoxic Conditions at Matched External Workload in Adults With Overweight and Obesity.
Sponsor: Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Summary
Obesity management involves lifestyle and dietary measures that include appropriate nutrition and increased physical activity (PA). Among the various PA options available, HIIT (High-Intensity Interval Training) workouts are now recognized as fun and effective programs for promoting fat loss. To date, in overweight or obese individuals, only two studies mention the benefits of HIIT performed under hypoxia for modulating body composition, and more specifically, reducing the amount of adipose tissue. These studies hypothesize an increased energy expenditure under hypoxia associated with a transient loss of appetite. In order, to further investigate the adaptations following HIIT under hypoxia versus normoxia, we propose to compare, in acute conditions, two HIIT sessions (simulated hypoxia-normobaric vs. normoxia) in overweight or obese subjects. The objective of this assessment is to compare, during exercise and recovery (+2h), oxygen consumption, corresponding energy expenditure, and carbohydrate and lipid utilization in hypoxic versus normoxic conditions. Given the potential influence of hypoxia on appetite, spontaneous food intake and energy expenditure post-24h will also be measured. Finally, since pleasure and perceived exertion are key parameters in adherence to an adapted physical activity (APA) program, these two concepts will also be evaluated through the subjects' experiences.
Official title: Comparison of HIIT Exercise Under Hypoxic and Normoxic Conditions in Adults With Overweight or Obesity: Impact on Oxygen Consumption, Carbohydrate and Lipid Substrate Utilization, and Appetite During Recovery.
Key Details
Gender
All
Age Range
50 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2024-11-01
Completion Date
2026-09-01
Last Updated
2026-09-11
Healthy Volunteers
No
Interventions
HIIE - Normoxia
Cycling HIIE in Normoxia: 60 x \[8 seconds at a power equivalent to 80-85% of HRmax followed by 12 seconds of active recovery at a power equivalent to 40% of HRmax\]
HIIE - Hypoxia
Cycling HIIE in Hypoxia (FiO2: 15%): 60 x \[8 seconds at a power equivalent to 80-85% of HRmax followed by 12 seconds of active recovery at a power equivalent to 40% of HRmax\]
Locations (1)
CREPS Auvergne Rhône-Alpes / Vichy
Bellerive-sur-Allier, Allier, France