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Endocannabinoids in Reward
Sponsor: Medical University of South Carolina
Summary
This study will examine sex differences in the effects of cannabis in people that regularly use it. Men and women that use cannabis at least 4 days a week will participate in a study involving 3 in-person visits. The first visit will be used to determine eligibility for the study. The other two visits will last 7 hours each and take place at least two days apart. Visits include administration of either THC, the chemical responsible for many of the psychoactive effects of cannabis, or a placebo; completion of questionnaires; and a 1-hour brain scan. One visit will also include a blood draw for genetic testing.
Official title: The Contribution of the Endocannabinoid System to Sex Differences in THC-associated Reward
Key Details
Gender
All
Age Range
21 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
78
Start Date
2026-10-01
Completion Date
2031-07-31
Last Updated
2026-10-05
Healthy Volunteers
No
Conditions
Interventions
Dronabinol
Oral dronabinol capsules (40 mg)
Placebo
Matched placebo capsules
Locations (1)
Medical University of South Carolina
Charleston, South Carolina, United States