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Meniscal Repair Augmented With Leukocyte-Poor Platelet-Rich Plasma: A Prospective Comparative Clinical Study
Sponsor: Universidad Autonoma de Nuevo Leon
Summary
This prospective, randomized, comparative clinical study will evaluate the clinical and functional outcomes of meniscal repair augmented with intraoperative intralesional leukocyte-poor platelet-rich plasma (LP-PRP) compared with conventional meniscal repair without biological augmentation. A total of 62 participants aged 18 to 40 years undergoing meniscal repair will be assigned to either the LP-PRP group or the control group. Participants will be followed for 6 months after surgery. Clinical outcomes will include knee function assessed using the International Knee Documentation Committee (IKDC) questionnaire, pain intensity assessed using the Visual Analog Scale (VAS), time to return to usual activities, and adverse events or complications. Assessments will be performed preoperatively and during postoperative follow-up at 2 weeks, 1 month, 3 months, and 6 months.
Official title: Clinical Outcomes and Postoperative Recovery Following Meniscal Repair Augmented With Intraoperative Intralesional Leukocyte-Poor Platelet-Rich Plasma: A Prospective Comparative Clinical Study
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
62
Start Date
2026-09
Completion Date
2027-10
Last Updated
2026-09-11
Healthy Volunteers
No
Conditions
Interventions
Leukocyte-poor platelet-rich plasma
Leukocyte-poor platelet-rich plasma (LP-PRP) will be prepared from approximately 60 mL of autologous venous blood using a standardized manual double-centrifugation technique. The LP-PRP will be activated with 10% calcium chloride and applied intraoperatively and intralesionally directly to the meniscal lesion between the sutured edges during meniscal repair.
Meniscal Repair
Participants will undergo meniscal repair using the surgical technique indicated according to the characteristics and location of the meniscal lesion. The same surgical and postoperative care principles will be applied to both study arms.
Locations (1)
Hospital Universitario "Dr. José Eleuterio González"
Monterrey, Nuevo León, Mexico