Clinical Research Directory

Inclusion Criteria: * Participant must be at least 18 years of age (or older, if required for adults by local regulations). * Screening CD4+ T-cell count ≥ 200 cells/µL. * Documented HIV-1 infection and screening plasma HIV-1 RNA ≥ 1 000 and ≤ 100 000 copies/mL. * Treatment-naïve. Prior use of oral pre-exposure prophylaxis (PrEP) or oral post-exposure prophylaxis (PEP) that is not INSTI or CAI based is permitted. * Body weight ≥ 50.0 kg (110 lbs) for participants assigned male at birth and ≥ 45.0 kg (99 lbs) for participants assigned female at birth. * Agrees to adequate birth control if a participant of childbearing potential Exclusion Criteria: * Participants with acute HIV-1 infection * Prior exposure to any HIV-1 capsid inhibitor or any HIV-1 INSTI for any reason is prohibited. * Participants with known or suspected presence of major virologic resistance mutations to study drugs * Unstable liver disease * Participants with HCV co-infection * Participant has evidence of chronic active HBV infection * Clinically significant cardiovascular disease