Clinical Research Directory

Inclusion Criteria: * Patients of either gender, over 65 years of age, able to understand the protocol procedures. * Known cardiovascular disease * Prediabetes or type 2 diabetes mellitus with HbA1c \< 7.0% on diet alone or metformin. Exclusion Criteria: * Age under 65 * Previous diagnosis of type 2 diabetes mellitus already undergoing drug therapy (except metformin) * Contraindications such as allergy to product components * Obesity secondary to diseases: genetic (Prader-Willi syndrome, Down syndrome); metabolic and endocrine (Cushing's syndrome, hypothyroidism) * Endocrine or liver disease or clinical evidence of chronic disease or gastrointestinal disorders or malabsorption disorders * History of adrenal adenoma or secondary arterial hypertension due to renal/adrenal causes * Arterial hypertension treated with an ACE inhibitor or ARB * Previous bariatric surgery