Clinical Research Directory
Browse clinical research sites, groups, and studies.
Development of a Noninvasive Metric to Measure Small Bowel Sensation - The Small Intestine Stress Test
Sponsor: Mayo Clinic
Summary
The purpose of this research is to identify the concentration of mannitol solution (a type of sugar alcohol) that will generate a range of symptoms in individuals without Disorders of Gut Brain Interaction (DGBI) to establish the normative range of responses to small bowel (SB) distension.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2026-08-24
Completion Date
2027-12-30
Last Updated
2026-09-14
Healthy Volunteers
Yes
Conditions
Interventions
Mannitol Solution 76 mOsm/L
Participants will ingest 500 mL of mannitol solution at 76 mOsm/L radiolabeled with 111Indium-DTPA during one testing visit.
Mannitol Solution 189 mOsm/L
Participants will ingest 500 mL of mannitol solution at 189 mOsm/L radiolabeled with 111Indium-DTPA during one testing visit.
Mannitol Solution 325 mOsm/L
Participants will ingest 500 mL of mannitol solution at 325 mOsm/L radiolabeled with 111Indium-DTPA during one testing visit.
Scintigraphy
Scintigraphy will be used to track gastric emptying, small bowel transit, and colonic filling of the radiolabeled mannitol solution during each testing visit.
Locations (1)
Mayo Clinic
Rochester, Minnesota, United States