Clinical Research Directory
Browse clinical research sites, groups, and studies.
Antibiotic Therapy in Impacted Mandibular Third Molar Surgery
Sponsor: Abant Izzet Baysal University
Summary
This study compared three antibiotic approaches in healthy young adults undergoing surgical removal of impacted lower wisdom teeth: a single dose of antibiotics before surgery, antibiotic treatment after surgery, and no antibiotics. Participants had similar impacted lower wisdom teeth on both sides and underwent surgery in two separate sessions. The study evaluated postoperative pain, facial swelling, mouth opening, and changes in blood markers related to inflammation, including C-reactive protein, erythrocyte sedimentation rate, procalcitonin, and white blood cell counts. The aim was to determine whether antibiotic use before or after surgery affected postoperative recovery and systemic inflammatory responses compared with no antibiotic use.
Official title: Effects of Preoperative and Postoperative Antibiotic Therapy on Clinical Outcomes and Systemic Inflammatory Biomarkers Following Impacted Mandibular Third Molar Surgery: A Prospective Randomized Double-Blind Split-Mouth Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2023-11-14
Completion Date
2024-12-26
Last Updated
2026-09-14
Healthy Volunteers
Yes
Conditions
Interventions
Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet
Amoxicillin-clavulanate 875/125 mg was administered twice daily for 7 days after surgery.
Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet
A single 2 g dose of amoxicillin-clavulanate was administered preoperatively as antibiotic prophylaxis before impacted mandibular third molar surgery.
Locations (1)
Bolu Abant Izzet Baysal University, Faculty of Dentistry
Bolu, Bolu, Turkey (Türkiye)