Clinical Research Directory

Molecular Imaging to Identify Predictors of Aortic Valve Disease Activity

Sponsor: Massachusetts General Hospital

Summary

This is a prospective study that aims to devlop clinical calculators that will report on the underlying rate of aortic valve calcification. To do so, baseline 18FNaF PET/CT will be obtained to measure AS disease activity, the rate of active microcalcification. Using these data, multi-omics prediction models and calculator tools will be developed to provide an index of ongoing disease activity (active calcification). Follow-up imaging (both echo and CT) will be performed 1 year after baseline imaging, to assess progression. We will test the hypothesis that baseline disease activity (as reported by the predictor models and calculators) associated with the rate of annualized AS progression in two cohorts (the same cohort, using subsequent imaging, as well as in the Population Study's cohorts.

Official title: Molecular Imaging and Deep Phenotyping to Identify Predictors of AS Disease Activity and Progression

Key Details

Conditions