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RECRUITING
NCT07820891
PHASE1

A Trial in Healthy Participants to Assess Drug Interaction Potential of BGB-43395

Sponsor: BeOne Medicines

View on ClinicalTrials.gov

Summary

This study will enroll healthy participants to evaluate whether BGB-43395 interacts with other drugs, including midazolam, celecoxib, dabigatran, and rosuvastatin.

Official title: A Phase 1, Open-label, Fixed-sequence Trial in Healthy Participants to Assess the Drug Interaction Potential of BGB-43395 With A Drug Cocktail Representative for CYP3A4, CYP2C9, P-gp, and BCRP Substrates

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

24

Start Date

2026-09-25

Completion Date

2026-11-22

Last Updated

2026-10-08

Healthy Volunteers

Yes

Interventions

DRUG

BGB-43395

Administered orally

DRUG

Midazolam

Administered orally

DRUG

Celecoxib

Administered orally

DRUG

Dabigatran etexilate

Administered orally

DRUG

Rosuvastatin

Administered orally

Locations (1)

Fortrea CRU

Dallas, Texas, United States