Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 years * Nondiabetic fasting plasma glucose (\< 7.0 mmol/L) at time of inclusion * BMI of 20-25 * Written informed consent Exclusion Criteria: * Haemoglobin \< 7.9 mmol/L * Pregnancy or breastfeeding * Significant gastrointestinal symptoms (e.g. dyspepsia, postprandial pain) * Use of medication that cannot be paused for 12 hours or any drug that affects gastric emptying, small intestinal motility, glucose absorption. * Use of paracetamol, NSAID, aspirin or similar within the previous week. * Evidence of drug abuse, consumption of tobacco in any form or daily consumption of more than 20g alcohol * History of gastrointestinal disease, including significant upper or lower gastrointestinal symptoms, pancreatitis, or previous gastrointestinal surgery including cholecystectomy (but not uncomplicated appendicectomy) * Participation in other research studies within the previous 3 months * Inability to give informed consent * Intolerance to any of the components of paracetamol and the meals used for the study