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COMPLETED
NCT07822256
NA

Chlorhexidine vs Essential Oil Mouthwash for Plaque Control

Sponsor: Rehman Medical Institute - RMI

View on ClinicalTrials.gov

Summary

Dental plaque is a sticky film of bacteria that forms on teeth and can lead to gum disease if it is not removed regularly. Brushing and flossing help control plaque, but many people also use a mouthwash to help clean areas that are hard to reach. This study compares two common types of mouthwash to see which one works better at reducing plaque: a mouthwash containing chlorhexidine (a medicated antibacterial ingredient) and a mouthwash containing essential oils (natural plant-based ingredients). Both are widely used, but they work in different ways and may cause different side effects. Sixty patients between the ages of 15 and 25 who had gum inflammation (gingivitis) took part. Half of the patients used the chlorhexidine mouthwash twice a day, and the other half used the essential oil mouthwash twice a day, for three months. Researchers measured the amount of plaque on each patient's teeth at the start of the study and again after three months, using a standard scoring method. They also recorded how well patients stuck to the mouthwash routine and any side effects they experienced, such as changes in taste, staining of the teeth, or a burning feeling in the mouth. The goal of this study is to help patients and dental care providers understand the benefits and drawbacks of each mouthwash, so they can choose the option that best fits their needs - whether that is stronger plaque control for a short period of time, or a milder option that may be more comfortable for longer-term use.

Official title: Comparing the Antiplaque Effects of Chlorhexidine Mouthwash and Essential Oil-Containing Mouthwash in Patients Reporting to Rehman College of Dentistry: A Randomized Clinical Trial

Key Details

Gender

All

Age Range

15 Years - 25 Years

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2026-02-03

Completion Date

2026-08-28

Last Updated

2026-09-16

Healthy Volunteers

No

Interventions

DRUG

Chlorhexidine Gluconate Mouthwash

A 0.2% chlorhexidine gluconate oral rinse used twice daily for 30 seconds over a three-month period. Chlorhexidine is a broad-spectrum antimicrobial agent with high substantivity, allowing it to bind to oral surfaces and provide sustained antiplaque action.

DRUG

Essential Oil mouthwash

An essential oil-containing oral rinse used twice daily over a three-month period. The formulation contains plant-derived antimicrobial compounds such as thymol and menthol, which act by disrupting microbial cell membrane integrity and reducing bacterial aggregation. Participants were instructed not to rinse with water after use.

Locations (1)

Rehman Medical Institute - RMI

Peshawar, Pakistan