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ASIGN Trial- Angulated Versus Standard Video-laryngoscope Blade in Nasal Intubation
Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Summary
This study compares two videolaryngoscope blade designs for nasal tracheal intubation in patients undergoing surgery under general anesthesia. Participants will be randomly assigned to undergo nasal tracheal intubation using either a hyperangulated C-MAC® D-BLADE® or a Macintosh-style videolaryngoscope blade. The study will evaluate the effectiveness of each approach by measuring time to successful intubation, number of intubation attempts, airway maneuvers required, and other procedural outcomes. Safety outcomes, including airway- and anesthesia-related adverse events, will also be assessed. The findings may help identify the most effective and safe videolaryngoscope blade design for nasal tracheal intubation.
Official title: Comparison Between C-MAC© Videolaryngoscope D-Blade Versus C-MAC© Videolaryngoscope Macin-tosh for Nasal Intubation. A Prospective Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
220
Start Date
2026-10-01
Completion Date
2028-10-30
Last Updated
2026-09-16
Healthy Volunteers
Yes
Conditions
Interventions
C-MAC® Videolaryngoscope D-BLADE®
The C-MAC® Videolaryngoscope D-BLADE® is a hyperangulated videolaryngoscope blade used for nasal tracheal intubation. Participants randomized to this intervention will undergo their initial study intubation attempt using the assigned D-BLADE® following induction of general anesthesia.
C-MAC® Videolaryngoscope Macintosh Blade
The C-MAC® Videolaryngoscope Macintosh Blade is a Macintosh-style videolaryngoscope blade used for nasal tracheal intubation. Participants randomized to this intervention will undergo their initial study intubation attempt using a size 3 or size 4 Macintosh blade, as clinically appropriate, following induction of general anesthesia.
Locations (1)
Mount Sinai Hospital
Toronto, Ontario, Canada