Clinical Research Directory

Inclusion Criteria: 【First-episode obsessive-compulsive disorder subgroup】 * Aged 18-60 years, no restriction on sex; * Meets DSM-5 diagnostic criteria for obsessive-compulsive disorder; * Junior high-school education or above; able to understand study-related information and complete questionnaires and examinations; * Has never received pharmacotherapy, psychological therapy or physical intervention for OCD; * Voluntarily participates in this study and provides written informed consent. 【Initial-treatment non-responder subgroup】 * Aged 18-60 years, no restriction on sex; * Meets DSM-5 diagnostic criteria for obsessive-compulsive disorder; * Junior high-school education or above; able to understand study-related information and complete questionnaires and examinations; * Has shown poor treatment response or intolerance after adequate-dose and adequate-duration treatment with one SSRI/SNRI agent, OR after receiving 12 sessions of cognitive-behavioral therapy (CBT); * Voluntarily participates in this study and provides written informed consent. 【Pharmacotherapy-resistant subgroup】 * Aged 18-60 years, no restriction on sex; * Meets DSM-5 diagnostic criteria for obsessive-compulsive disorder; * Junior high-school education or above; able to understand study-related information and complete questionnaires and examinations; * Demonstrates poor treatment response or intolerance following adequate-dose and adequate-duration treatment with two or more different SSRI/SNRI agents; * Voluntarily participates in this study and provides written informed consent. Exclusion Criteria: * Meets the diagnosis criteria in DSM-5 except for obsessive-compulsive disorder (excluding obsessive-compulsive personality disorder); * The obsessive symptoms are severe and prevent the patient from completing the required assessment tests; * Pregnant or women who are about to become pregnant, lactating women; * Have severe negative thoughts or a high risk of suicide; * Have a history of other substance dependence or excessive use in the past year; 6) Other situations deemed unsuitable for inclusion by the researchers.