Clinical Research Directory

Inclusion Criteria: * Stage III or IV periodontitis patient having at least one tooth with 2-wall, 3-wall, or combined 2- to 3-wall intrabony defect ≥ 3 mm in depth (assessed by bone sounding, radiographic examination) with pocket depth (PD) ≥ 6 mm. * Able to sign an informed consent form. * Patients who are cooperative, motivated, and hygiene conscious. * Systemically free according to Cornell Medical Index (Broadbent, 1951). Exclusion Criteria: * Pregnancy or breast feeding * Smoking (current or in the past 5 years). * The presence of an orthodontic appliance * Periodontal therapy carried out in the past 6 months * History of intake of antibiotics or other medications affecting the periodontium in the previous 3 months. * Handicapped and patients with psychological conditions.