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Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy
Sponsor: University of Miami
Summary
This study looks at a non-invasive ear stimulation treatment to better understand nerve pain in people living with HIV. The study aims to assess how the body and nervous system respond to this treatment, including changes in heart function and pain signals. The goal is to learn how future treatments for nerve pain may be improved.
Official title: Mechanistic Modulation of HIV-Associated Peripheral Neuropathy in Older Adults Via Auricular Vagus Nerve Stimulation
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2026-11
Completion Date
2028-09-30
Last Updated
2026-10-06
Healthy Volunteers
No
Conditions
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation (AVNS)
Transcutaneous auricular vagus nerve stimulation (taVNS) will be administered at the cymba concha using hydrogel electrodes and a Digitimer DS8R biphasic constant-current stimulator. Participants will receive 90-minute stimulation sessions consisting of monophasic pulses (pulse width: 500 microseconds; frequency: 25 Hz; duty cycle: 50%). Stimulation intensity will be set at 200% of the participant's sensory perception threshold and may be adjusted up to 5 milliamperes (mA) while remaining below the pain threshold.
Locations (1)
Christine E Lynn Rehabilitation Center
Miami, Florida, United States