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RECRUITING
NCT07822932
NA

Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy

Sponsor: University of Miami

View on ClinicalTrials.gov

Summary

This study looks at a non-invasive ear stimulation treatment to better understand nerve pain in people living with HIV. The study aims to assess how the body and nervous system respond to this treatment, including changes in heart function and pain signals. The goal is to learn how future treatments for nerve pain may be improved.

Official title: Mechanistic Modulation of HIV-Associated Peripheral Neuropathy in Older Adults Via Auricular Vagus Nerve Stimulation

Key Details

Gender

All

Age Range

50 Years - Any

Study Type

INTERVENTIONAL

Enrollment

70

Start Date

2026-11

Completion Date

2028-09-30

Last Updated

2026-10-06

Healthy Volunteers

No

Interventions

DEVICE

Transcutaneous Auricular Vagus Nerve Stimulation (AVNS)

Transcutaneous auricular vagus nerve stimulation (taVNS) will be administered at the cymba concha using hydrogel electrodes and a Digitimer DS8R biphasic constant-current stimulator. Participants will receive 90-minute stimulation sessions consisting of monophasic pulses (pulse width: 500 microseconds; frequency: 25 Hz; duty cycle: 50%). Stimulation intensity will be set at 200% of the participant's sensory perception threshold and may be adjusted up to 5 milliamperes (mA) while remaining below the pain threshold.

Locations (1)

Christine E Lynn Rehabilitation Center

Miami, Florida, United States