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Technical Development of Xe MRI
Sponsor: Children's Hospital Medical Center, Cincinnati
Summary
The goal of this study is to develop and optimize new proton (1H; conventional MRI) and Xe gas MRI techniques to assess regional cardiopulmonary structure and function in the clinical setting. Specifically, three forms of Xe MRI techniques will be our focus: (1) imaging of the Xe ventilation distribution (which is the current FDA-approved indication for Xe MRI); (2) imaging the alveolar microstructure via the Xe apparent diffusion coefficient (ADC); and (3) detecting via spectroscopy and imaging Xe gas dissolved in the pulmonary blood and tissues upon inhalation.
Official title: Technical Development of Xe MRI in Children and Adults
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
550
Start Date
2024-01-01
Completion Date
2030-01
Last Updated
2026-09-16
Healthy Volunteers
Yes
Conditions
Interventions
Hyperpolarized 129 Xenon
The total dosing volume will be consistent with CCHMC Department of Radiology clinical standards or up to 1/6th of a participant's total lung capacity (calculated or predicted from ATS guidelines or from participant's plethysmography data if available within 6 months of MRI scan) for participants under 18 years old and 1000 milliliters for adults. No more than a total of five Xe gas doses, combined clinical and research doses, will be administered during the scanning session.
Locations (1)
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States