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Efficacy and Safety of Intrapleural Fibrinolytic Therapy in Tuberculous Pleural Effusion Versus Non-Tuberculous Pleural Infection
Sponsor: National University of Malaysia
Summary
This retrospective cohort study evaluates the efficacy and safety of intrapleural fibrinolytic therapy (tPA/DNase) in patients with tuberculous pleural effusion compared with non-tuberculous pleural infection at Hospital Canselor Tuanku Muhriz (HCTM), Malaysia. The study aims to compare radiological improvement, clinical outcomes, and treatment-related adverse events to provide evidence supporting the use of IPFT in tuberculous pleural effusion.
Official title: Efficacy and Safety of Intrapleural Fibrinolytic Therapy in Tuberculous Pleural Effusion Versus Non-Tuberculous Pleural Infection: A Ten-Year Retrospective Study at Hospital Canselor Tuanku Muhriz (FIB-TB Study)
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
160
Start Date
2026-09-20
Completion Date
2027-06-01
Last Updated
2026-09-16
Healthy Volunteers
No
Conditions
Interventions
Intrapleural Fibrinolytic Therapy (IPFT)
Patients received intrapleural fibrinolytic therapy with alteplase and DNase through an intercostal chest tube for management of complicated pleural infection. Clinical outcomes following IPFT were compared between patients with tuberculous pleural effusion and non-tuberculous pleural effusion.
Locations (1)
National University of Malaysia
Kuala Lumpur, Kuala Lumpur, Malaysia